Background: Numerous risk prediction tools include clinical risk factors such as blood lipids or blood pressure to estimate an individual’s short-term (i.e.10-year) risk of cardiovascular disease (CVD). However, those tools often underestimate risk burden in young adults (<50 years) and, thus, their long-term CVD risk. Moreover, they are not well-suited for primordial cardiovascular prevention. The Healthy Heart Score is a 20-year CVD risk prediction tool based on 9 modifiable health behaviors: smoking status, alcohol intake, body mass index, physical activity, dietary fiber intake, fruit/vegetables, nuts, sugar-sweetened beverages, and red/processed meats. This tool has been derived and validated in two large cohorts at Harvard University. However, before a risk tool can be widely used, it is important to show its validity among other populations and age groups. Objectives: to validate the Healthy Heart Score in a large cohort representative of the Spanish population over the age of 18 years, re-calibrate if necessary, identify the most relevant components in our population, to asses if it can predict other adverse health outcomes, and transfer it to a worksite population through the development of an interactive free-access app/web. Methods: The Healthy Heart Score validation in a Spanish cohort (ENRICA; >12,000 participants) will be done using gender-specific beta-coefficients from the Harvard Cohorts. Model discrimination will be assessed using Harrell’s C-index for survival data. Model calibration will be evaluated through calibration plots, plotting the average predicted risk against the observed risk in deciles of predicted risk. Re-calibration will be considered using cohort specific coefficients. Semi-structured in person interviews among the workers and health professionals to know the feasibility and acceptability of the Spanish Healthy Heart Score web/application will be done following guidelines for qualitative studies (COREQ).

Epidemiología nutricional
prevencion primordial
estilos de vida
enfermedad cardiovascular
ecuación de riesgo
traslación
aplicación móvil

Acción Estratégica en Salud (AES)