The effectiveness of Mesenchymal stem cells (MSCs) in regenerative medicine greatly depends on their paracrine function. The process of ageing and, in women, the decrease in oestrogen levels during menopause, lead to the development of a highly pro-inflammatory microenvironment at the bone marrow (BM). This hostile microenvironment greatly impacts the regenerative potential of Bone Marrow Mesenchymal stem cells (BM-MSCs) as well as their paracrine activity. The composition of the MSCs’ secretome influences the activity of all resident cells at the BM, including those involved in bone homeostasis. In this project we aim to dissect the changes in the secretome composition of osteoporotic MSCs and how those changes influence the activities of other cells in the BM microenvironment. The identification of the molecules and molecular mechanisms regulating the activity of cells responsible of bone homeostasis would allow us to design specific therapeutic strategies to modulate the composition of this microenvironment, counteracting its negative effects and thus, creating a microenvironment that favors bone regeneration.

Osteoporosis
envejecimiento
células madre mesenquimales
secretoma
regeneracíon ósea.

Acción Estratégica en Salud (AES)